FGF21 mediates the lipid metabolism response to amino acid starvation
2013; Elsevier BV; Volume: 54; Issue: 7 Linguagem: Inglês
10.1194/jlr.m033415
ISSN1539-7262
AutoresAna Luísa De Sousa‐Coelho, Joana Relat, Elayne Hondares, Albert Pérez‐Martí, Francesc Ribas‐Aulinas, Francesc Villarroya, Pedro F. Marrero, Diego Haro,
Tópico(s)Kruppel-like factors research
ResumoLipogenic gene expression in liver is repressed in mice upon leucine deprivation. The hormone fibroblast growth factor 21 (FGF21), which is critical to the adaptive metabolic response to starvation, is also induced under amino acid deprivation. Upon leucine deprivation, we found that FGF21 is needed to repress expression of lipogenic genes in liver and white adipose tissue, and stimulate phosphorylation of hormone-sensitive lipase in white adipose tissue. The increased expression of Ucp1 in brown adipose tissue under these circumstances is also impaired in FGF21-deficient mice. Our results demonstrate the important role of FGF21 in the regulation of lipid metabolism during amino acid starvation.
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