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Factors Associated With Disability in Patients With Rheumatoid Arthritis

2010; Lippincott Williams & Wilkins; Volume: 16; Issue: 5 Linguagem: Inglês

10.1097/rhu.0b013e3181e92d25

1536-7355

Emilce Edith Schneeberger, Gustavo Citera, J. A. Maldonado Cocco, Mariana Salcedo, Flavia Chiardola, Marcos Rosemffet, María Florencia Marengo, Sílvia Papasidero, Rafael Chaparro del Moral, Oscar Rillo, Verónica Bellomio, Eleonora Lucero, Alberto Spindler, Alberto Berman, Damián Duartes Noé, Juan Carlos Barreira, María Alicia Lázaro, Sergio Paira,

Autoimmune and Inflammatory Disorders Research

Analyze disability determinants in a cohort of Argentine patients with rheumatoid arthritis (RA).Consecutive patients with RA, according to ACR'87 criteria, were recruited from 6 rheumatology centers. Demographic and socioeconomic data, family history, comorbid diseases, extra-articular manifestations and information about received treatments were provided. Disease activity was assessed using Disease Activity Score 28 (DAS 28) and the Health Assessment Questionnaire (HAQ)-A was used for the functional capacity. Hand and feet radiographs were assessed using Sharp-van der Heijde score.A total of 640 patients with RA were included, of which 85.2% were females. Mean age was 53 years (interquartile range [IQR], 44-62) and mean disease duration was 8 years (IQR, 4-14). DAS 28 mean was 2.72 (IQR, 1.7-3.7) and HAQ-A mean was 0.62 (IQR, 0.13-1.25). Multiple linear regression showed that the main variables associated with disability were DAS 28, radiologic damage and age. Main predictors of functional disability in the multiple logistic regression using severe HAQ (>2) as dependent variable were DAS 28 (OR, 2; P < 0.0001); age (OR, 1; P = 0.008); and structural damage (OR, 1; P = 0.001).In this population, the disease activity was the variable that showed the highest impact on the physical function. Radiologic damage affected HAQ as the disease progressed.