Portal de Periódicos da CAPES

Chlorinated hydrocarbon toxicity in the fowl and duck

1970; Elsevier BV; Volume: 80; Issue: 3 Linguagem: Inglês

10.1016/0021-9975(70)90079-4

1532-3129

John Sinclair Lawrence Fowler,

Pharmacogenetics and Drug Metabolism

Carbon tetrachloride was administered orally to cockerels and ducks. Blood concentrations were determined at intervals. Metabolites of carbon tetrachloride were not detected in cockerels or ducks. In contrast hexachloroethane was metabolised to pentachloroethane and tetrachloroethylene as occurs in mammals. Aspartate aminotransferase, iditol dehydrogenase and glutamate dehydrogenase activities were determined in extracts of liver, kidney, spleen, in cardiac, skeletal and gizzard muscle, and in pancreas, small intestine, lung, brain and plasma from cockerels and ducks. A moderate increase in plasma aspartate aminotransferase activity (p=<0·01) occurred after administration of carbon tetrachloride, but was not accompanied by significant increases in plasma activities of other enzymes (p=⊀0·3) or by changes in BSP transfer rates. These findings are consistent with the hypothesis that the toxicity of carbon tetrachloride in the mammal is due to an active metabolite.