Portal de Periódicos da CAPES

GABA A Receptors in Central Nervous System Disease: Anxiety, Epilepsy, and Insomnia

2006; Taylor & Francis; Volume: 26; Issue: 5-6 Linguagem: Inglês

10.1080/10799890600920035

1532-4281

Hanns Möhler,

Tryptophan and brain disorders

Brain function is based on an exquisite balance between excitatory and inhibitory neurotransmission. GABAergic neurons provide the major inhibitory control. By controlling spike timing and sculpting neuronal rhythms they play a key role in regulating behavior. GABAergic neurons are highly diverse and operate with a corresponding diversity of GABAA receptor subtypes. In this article, the contribution of GABAA receptor deficits to central nervous system disorders, in particular anxiety disorders, epilepsy, schizophrenia and insomnia, is reviewed.