New anchors useful in solid phase peptide synthesis, evidence of an unexpected polyacrylic supported reaction by non destructive 13c NMR spectrosco
1988; Elsevier BV; Volume: 44; Issue: 14 Linguagem: Inglês
10.1016/s0040-4020(01)86143-3
ISSN1464-5416
AutoresJean‐Claude Alfred, Jean‐Louis Aubagnac, Monique Calmès, Jacques Daunis, Btissan Elamrani, Robert Jacquier, G. NKUSI,
Tópico(s)Biochemical and Structural Characterization
ResumoA polyacrylic resin with NH2 functions was made to react with α-bromoacetic anhydrides with the view of finding new anchors useful in solid phase peptide synthesis. Besides the normal amide product, the process with α -bromopropionic acid anhydride gave rise to α β-alanine derivative whose structure was determined by non destructive 13C NMR spectroscopy and tandem mass spectronietry.
Referência(s)