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BIBTEX RIS

Identification of an Active Sequence within the First Immunoglobulin Domain of Intercellular Cell Adhesion Molecule-1 (ICAM-1) That Interacts with Fibrinogen

1996; Elsevier BV; Volume: 271; Issue: 39 Linguagem: Inglês

10.1074/jbc.271.39.24270

ISSN

1083-351X

Autores

Stanley E. D’Souza, V Byers-Ward, Elizabeth E. Gardiner, Hongwu Wang, Shen Shu Sung,

Tópico(s)

Monoclonal and Polyclonal Antibodies Research

Resumo

Monocytic cells bind fibrinogen (fg) through integrin αMβ2. fg-bound monocytic cells demonstrate an enhanced adhesion to endothelial cells, which is dependent on intercellular adhesion molecule-1 (ICAM-1). Our studies differentiate fg interactions with stimulated and resting endothelial cells, which are ICAM-1 dependent and independent, respectively. This report documents a direct interaction between fg and intact ICAM-1 and with a two-Ig domain form of ICAM-1. A small region within the first Ig domain of ICAM-1, ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar) (KVILPRGGSVLVTC), was identified to interact with fg in a specific and selective manner. ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar) bound to plasmin-derived fg fragments X, D100, and D80 but not to fragment E. Consistent with this finding, fg γ-chain peptide, fg-γ-117-133, blocked fg interaction with ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar). ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar) peptide and antibodies directed against ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar) also blocked the adhesion and binding of ICAM-1-bearing Raji cells with fg. ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar) and fg-γ-117-133 are likely to be one of the contact pairs mediating fg-ICAM-1 interactions. Monocytic cells bind fibrinogen (fg) through integrin αMβ2. fg-bound monocytic cells demonstrate an enhanced adhesion to endothelial cells, which is dependent on intercellular adhesion molecule-1 (ICAM-1). Our studies differentiate fg interactions with stimulated and resting endothelial cells, which are ICAM-1 dependent and independent, respectively. This report documents a direct interaction between fg and intact ICAM-1 and with a two-Ig domain form of ICAM-1. A small region within the first Ig domain of ICAM-1, ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar) (KVILPRGGSVLVTC), was identified to interact with fg in a specific and selective manner. ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar) bound to plasmin-derived fg fragments X, D100, and D80 but not to fragment E. Consistent with this finding, fg γ-chain peptide, fg-γ-117-133, blocked fg interaction with ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar). ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar) peptide and antibodies directed against ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. Proteins Struct. Funct. Genet. 1990; 7: 227-233Crossref PubMed Scopus (38) Google Scholar, 13Alzari P.M. Lascombe M.-B. Poljak R.J. Annu. Rev. Immunol. 1988; 6: 555-580Crossref PubMed Scopus (202) Google Scholar, 14Williams A.F. Barclay A.N. Annu. Rev. Immunol. 1988; 6: 381-405Crossref PubMed Scopus (1743) Google Scholar, 15Marlin S.D. Springer T.A. Cell. 1987; 51: 813-819Abstract Full Text PDF PubMed Scopus (1374) Google Scholar, 16Diamond M.S. Staunton D.E. Marlin S.D. Springer T.A. Cell. 1991; 65: 961-971Abstract Full Text PDF PubMed Scopus (639) Google Scholar, 17Springer T.A. Annu. Rev. Physiol. 1995; 57: 827-872Crossref PubMed Scopus (1352) Google Scholar, 18Xu H. Gonzalo J.A. Pierre St., Y. Williams I.R. Kupper T.S. Cotran R.S. Springer T.A. Gutierrez-Ramos J.-C. J. Exp. Med. 1994; 180: 95-109Crossref PubMed Scopus (434) Google Scholar, 19Languino L.R. Duperray A. Joganic K.J. Fornaro M. Thornton G.B. Altieri D.C. Proc. Natl. Acad. Sci. U. S. A. 1995; 92: 1505-1509Crossref PubMed Scopus (163) Google Scholar, 20Faull R.J. Russ G.R. Transplantation. 1989; 48: 226-230Crossref PubMed Scopus (143) Google Scholar, 21Fecondo J.V. Kent S.B.H. Boyd A.W. Proc. Natl. Acad. Sci. U. S. A. 1991; 88: 2879-2882Crossref PubMed Scopus (31) Google Scholar) also blocked the adhesion and binding of ICAM-1-bearing Raji cells with fg. ICAM-1-(8Altieri D.C. Bader R. Mannucci P.M. Edgington T.S. J. Cell Biol. 1988; 107: 1893-1900Crossref PubMed Scopus (297) Google Scholar, 9Altieri D.C. Plescia J. Plow E.F. J. Biol. Chem. 1993; 268: 1847-1853Abstract Full Text PDF PubMed Google Scholar, 10Staunton D.E. Dustin M.L. Springer T.A. Nature. 1989; 339: 61-64Crossref PubMed Scopus (668) Google Scholar, 11de Fougerolles A.R. Qin X. Springer T.A. J. Exp. Med. 1994; 179: 619-629Crossref PubMed Scopus (149) Google Scholar, 12Giranda V.L. Chapman M.S. Rossmann M.G. 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