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Transforming growth factor‐ β : A bidirectional regulator of hematopoietic cell growth

1992; Wiley; Volume: 10; Issue: 1 Linguagem: Inglês

10.1002/stem.5530100103

0737-1454

Jonathan R. Keller, Sten Eirik W. Jacobsen, Claire M. Dubois, Kjetil Hestdal, Francis W. Ruscetti,

Myeloproliferative Neoplasms: Diagnosis and Treatment

It is now apparent that the transforming growth factor-β (TGF-β) family of proteins has potent hematopoietic regulatory properties ranging from effects on the growth and differentiation of primitive stem cells to the differentiated functions of mature cells. Although most reports have described the inhibitory activities of TGF-β on hematopoiesis, recent evidence supports the concept that TGF-β can have both inhibitory and stimulatory actions on these systems. These differences depend on the differentiation state of the target cell and the other cytokines interacting with the cell. Furthermore, TGF-β has direct bidirectional effects on cell surface expression of many cytokine receptors suggesting that it is part of the mechanism of action of TGF-β. The major biological effect of TGF-β on hematopoietic cell growth is the reversible inhibition of entry into the cell cycle. Importantly, the effect of in vivo administration of TGF-β has mimicked the in vitro effects. Ultimately, well designed clinical trials will determine whether the exciting potential of TGF-β can be used to treat or prevent myelotoxicity and other bone marrow dysfunctions.