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Serine/threonine kinases in the nervous system

1991; Elsevier BV; Volume: 1; Issue: 1 Linguagem: Inglês

10.1016/0959-4388(91)90009-v

1873-6882

Howard Schulman,

Protein Structure and Dynamics

Three principal serine/threonine kinases that catalyze protein phosphorylation in response to second messengers are: CAMP-dependent protein kinase, multifunctional Ca2+/calmodulin-dependent protein kinase, and protein kinase C. Studies are now focusing on the distinct isoforms of these kinases that may subserve specific functions in some systems, and on providing a more molecular understanding of kinase functions. Combined genetic and biochemical approaches are beginning to be used to define unique roles for these kinases.