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Mammalian DSCAMs: roles in the development of the spinal cord, cortex, and cerebellum?

2002; Elsevier BV; Volume: 293; Issue: 3 Linguagem: Inglês

10.1016/s0006-291x(02)00307-8

1090-2104

Gillian Barlow, Bruce Micales, Xiao–Ning Chen, Gary E. Lyons, Julie R. Korenberg,

Neuroscience and Neuropharmacology Research

Central nervous system (CNS) development involves neural patterning, neuronal and axonal migrations, and synapse formation. DSCAM, a chromosome 21 axon guidance molecule, is expressed by CNS neurons during development and throughout adult life. We now report that DSCAM and its chromosome 11 paralog DSCAML1 exhibit inverse ventral–dorsal expression patterns in the developing spinal cord and distinct, partly inverse, expression patterns in the developing cortex, beginning in the Cajal–Retzius cells. In the adult cortex, DSCAM predominates in layer 3/5 pyramidal cells and DSCAML1 predominates in layer 2 granule cells. In the cerebellum, DSCAM is stronger in the Purkinje cells and DSCAML1 in the granule cells. Finally, we find that the predicted DSCAML1 protein contains 60 additional N-terminal amino acids which may contribute to its distinct expression pattern and putative function. We propose that the DSCAMs comprise novel elements of the pathways mediating dorsal–ventral patterning and cell-fate specification in the developing CNS.