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Developing an international network for Alzheimer’s research: the Dominantly Inherited Alzheimer Network

2012; OMICS Publishing Group; Volume: 2; Issue: 10 Linguagem: Inglês

10.4155/cli.12.93

2041-6806

John C. Morris, Paul S. Aisen, Randall J. Bateman, Tammie L.S. Benzinger, Nigel J. Cairns, Anne M. Fagan, Bernardino Ghetti, Alison Goate, David M. Holtzman, William E. Klunk, Eric McDade, Daniel S. Marcus, Ralph N. Martins, Colin L. Masters, Richard Mayeux, Angela Oliver, Kimberly A. Quaid, John M. Ringman, Martin N. Rossor, Stephen Salloway, Peter R. Schofield, Natalie J. Selsor, Reisa A. Sperling, Michael W. Weiner, Chengjie Xiong, Krista L. Moulder, Virginia Buckles,

Parkinson's Disease Mechanisms and Treatments

The Dominantly Inherited Alzheimer Network (DIAN) is a collaborative effort of international Alzheimer disease (AD) centers that are conducting a multifaceted prospective biomarker study in individuals at-risk for autosomal dominant AD (ADAD). DIAN collects comprehensive information and tissue in accordance with standard protocols from asymptomatic and symptomatic ADAD mutation carriers and their non-carrier family members to determine the pathochronology of clinical, cognitive, neuroimaging, and fluid biomarkers of AD. This article describes the structure, implementation, and underlying principles of DIAN, as well as the demographic features of the initial DIAN cohort.