Alterations in human serum alkaline phosphatase and its isoenzymes by hypolipidemic agents: Colestipol and clofibrate
1983; Elsevier BV; Volume: 32; Issue: 8 Linguagem: Inglês
10.1016/0026-0495(83)90113-0
ISSN1532-8600
AutoresJeffrey L. Probstfield, Bernard E. Statland, Linda K. Gorman, Donald B. Hunninghake,
Tópico(s)Pancreatitis Pathology and Treatment
ResumoTotal serum alkaline phosphatase (TSAP) determinations were done as part of the biochemical screening in comparative studies of lipid lowering agents in type lla hyperlipoproteinemic patients. TSAP determinations were made by using a modification of the Bessey-Lowry method and the Statland method. Increases in TSAP following colestipol treatment of 20% (P < 0.05) and 32% (P < 0.005) were seen by using the respective methods. Isoenzymatic determinations were done by employing the Statland method and all fractions were increased from baseline levels during colestipol therapy. Clofibrate was associated with 34% (P < 0.005) and 28% (P < 0.005) reductions in TSAP activity by using the respective methods; significant reductions in both “bone” and “other” isoenzymatic components occurred. Gamma-glutamyltransferase (γGT) results did not consistently reflect TSAP or “liver” isoenzyme results.
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