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Long-term intracerebral inflammatory response after traumatic brain injury

2004; Elsevier BV; Volume: 146; Issue: 2-3 Linguagem: Inglês

10.1016/j.forsciint.2004.06.027

1872-6283

Steve Gentleman, Pascale D. Leclercq, Lisa H Moyes, David I. Graham, Colin Smith, W. Sue T. Griffin, James A. R. Nicoll,

Traumatic Brain Injury and Neurovascular Disturbances

Epidemiological and pathological studies suggest that head injury is a significant risk factor for subsequent neurodegeneration and cognitive decline in later life. The precise mechanisms for the development of post-traumatic neurodegenerative change are unclear but we hypothesize that persistence of inflammatory processes in the brain may play a key role and that some individuals are more susceptible to such changes based on their genetic make-up. In support of this hypothesis we present evidence of persistent elevated microglial activity in long-term survivors of head injury and the suggestion of an association between the extent of this activity and interleukin-1 genotype.