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BIBTEX RIS

The potential use of heat-shock proteins to vaccinate against mycobacterial infections

1999; Elsevier BV; Volume: 1; Issue: 6 Linguagem: Inglês

10.1016/s1286-4579(99)80046-x

1769-714X

Célio Lopes Silva,

Escherichia coli research studies

Over the last few years, some of our experiments in which mycobacterial heat-shock protein (HSP) antigens were presented to the immune system as if they were viral antigens have had a significant impact on our understanding of protective immunity against tuberculosis. They have also markedly enhanced the prospects for new vaccines. We now know that the mycobacterial HSP65 antigen can confer protection equal to that from live BCG vaccine in mice.