The Kveim test in sarcoidosis
1961; Elsevier BV; Volume: 30; Issue: 4 Linguagem: Inglês
10.1016/0002-9343(61)90074-2
ISSN1555-7162
Autores Tópico(s)Sarcoidosis and Beryllium Toxicity Research
ResumoThe Kveim Test in Sarcoidosis T HE cloud of uncertainty about the validity of the Kveim test in the diagnosis of sarcoidosis seems to be lifting gradually.For some twenty years favorable experiences with this diagnostic procedure have been accumulating in this country [Y-4] and abroad, particularly in Norway [5,6], Denmark [7], Great Britain [8] and New Zealand [9,70].More than 1,000 patients around the world have now been tested in this way, by intracutaneous injection of suspensions of sarcoidal lymph node or splenic tissue, usually prepared locally.With preparations of satisfactory specificity and sensitivity, it has generally been found that about three of every four patients with active sarcoidosis respond.In them, a papule is induced at the site of injection which, on punch biopsy performed under local anesthesia four to six weeks after injection, shows epithelioid-cell tubercles similar to those seen in the spontaneously occurring lesions."False-positive" reactions are uncommon, being exhibited by about 2 per cent of non-sarcoid subjects, when the test is properly performed [II].*Unfavorable opinions about the worth of the test may have stemmed, in part, from the use of unsuitable test preparations [72].Until recently, screened test material has been in too short supply for general distribution.
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