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Two New Bisacridone Alkaloids from Citrus Plants1

1996; Elsevier BV; Volume: 42; Issue: 1 Linguagem: Inglês

10.3987/com-95-s12

1881-0942

Motoharu Ju‐ichi, Yuko Takemura, Noriko Nagareya, Mitsuo Omura, Chihiro Ito, Hiroshi Furukawa,

Chemical synthesis and alkaloids

Two new binary acridone alkaloids named citbismine-D (1) and -E (2) were isolated from the roots of Marsh grapefruit (Citrus paradisi).The structures were elucidated by spectroscopic studies as 1 and 2. Citbismine-E (2) was also obtained from the roots of Hirado-Buntan (C.grandis).Previous chemical studies in our laboratory of the constituents of Citrus plants (Rutaceae) have resulted in the isolation of many acridone alkaloids,2 coumarins3 and acridone-coumarin dirnem4 Recently, we reported the isolation and structure elucidation of new type bisacridone alkaloid citbismine-A5 from the roots of Marsh grapefruit (C.paradisi Macf.) and Hirado-Buntan (C.grandis Osbeck f.Hirado).Further study of these plants resulted in the isolation of two additional bisacridone alkaloids named citbismine-D (1) and -E (2).This paper deals with the structure elucidation of these alkaloids.Citbismine-D (1) was obtained from the roots of Marsh grapefruit as a pale yellow oil, [a]2:_y)0