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Candida albicans isoladas da cavidade bucal de crianças com síndrome de Down: ocorrência e inibição do crescimento por Streptomyces sp

2005; Brazilian Society of Tropical Medicine; Volume: 38; Issue: 5 Linguagem: Inglês

10.1590/s0037-86822005000500003

1678-9849

José Daniel Gonçalves Vieira, Evandro Leão Ribeiro, Cerise de Castro Campos, Fabiana Cristina Pimenta, Orlando Ayrton de Toledo, Gustavo Morais Nagato, Niwmar Alves de Souza, Wesley Magno Ferreira, Cléver Gomes Cardoso, Sueli Meira da Silva Dias, César Aparício de Araújo Júnior, Daniel Teles Zatta, Juliana de Sousa dos Santos,

Oral health in cancer treatment

Comparison of the presence of Candida yeasts in the buccal cavity of children without and with Down's syndrome showed a statistically significant difference in the case of children that were affected by this chromosomopathy, rendering them more predisposed to buccal candidiasis, probably due to anatomicophysiologic alterations of the mouth resulting from trisomy of chromosome 21. Constant recurrence of buccal candidiasis in children with this chromosomal alteration lead to the search for a possible therapeutic alternative. Seeking to determine the antifungal activity of Streptomyces sp isolated from various Brazilian soils, 5 strains have been tested for Candida albicans isolated from the buccal cavity of children with Down's syndrome. It was observed that the isolate presented a diversity in the size of the halos (9-31 mm in diameter) of growth inhibition of the yeasts, suggesting a possible use as a therapeutic antifungal.