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Acute Renal Failure after Binge Drinking of Alcohol and Nonsteroidal Antiinflammatory Drug Ingestion.

1997; The Japanese Society of Internal Medicine; Volume: 36; Issue: 2 Linguagem: Inglês

10.2169/internalmedicine.36.102

1349-7235

Nobuo Tsuboi, Hiroaki Yoshida, Kazuhisa SHIBAMURA, Miho Hikita, Haruo Tomonari, Satoru Kuriyama, Osamu Sakai,

Alcoholism and Thiamine Deficiency

A case of reversible acute renal failure (ARF) following binge drinking together with the transient use of a nonsteroidal antiinflammatory drug (NSAID) is described. After binge drinking, the patient experienced hyperdipsia, and the volume of his urine decreased. Subsequently, he took an NSAID to relieve systemic joint pain associated with low grade fever, and then he had complete anuria. One day after taking the NSAID, he visited our hospital, and was found to have severe renal dysfunction accompanied by severe liver damage (blood urea nitrogen and creatinine concentrations were 57 and 5.4 mg/dl, respectively). The impaired renal function progressed over the first three hospital days, as reflected by an elevated creatinine concentration to 11.6 mg/dl. Nine treatment sessions of hemodialysis were, therefore, required to recover the loss of renal function. The present case suggests that binge drinking may be a potential risk factor for ARF in the presence of NSAIDs.(Internal Medicine 36:102-106, 1997)