Portal de Periódicos da CAPES

The Molecular Epidemiology of HIV Type 1 of Men in Mexico

2001; Mary Ann Liebert, Inc.; Volume: 17; Issue: 1 Linguagem: Inglês

10.1089/088922201750056825

1931-8405

Lydia Guadalupe Rivera-Morales, Vladimir Novitsky, J. Roberto Trujillo, Carlos Lavalle-Montalvo, Carlos Cano-Dominguez, Javier Ramos‐Jiménez, Eusebio Jimenez-Rios, Leopoldo Flores-Flores, Paulo López-Guillén, Peter B. Gilbert, Fredrik Vannberg, Reyes Taméz-Guerra, Cristina Rodríguez‐Padilla, Max Essex,

vaccines and immunoinformatics approaches

Genotypic characteristics of human immunodeficiency virus type 1 (HIV-1) in Mexico were investigated in a multicenter study that involved centers in five geographic regions of the country. Study samples (n = 65) collected from male patients in 1998-1999 were sequenced within the C2-V5 region of the gp120 env gene. Phylogenetic analysis revealed that subtype B predominates in Mexico. The level of interpatient nucleotide diversity (mean value of 8.9%) was congruent with multiple introductions of the virus and the "aging" epidemic in Mexico. One-third of samples (30.8% of cases) showed polymorphism within the crown of the V3 loop demonstrating non-GPGR motifs. Two new motifs in the V3 loop crown - HPGG and GPEG - were observed. The evolution of the AIDS epidemic in Mexico should be closely monitored since non-B HIV-1 subtypes might be introduced. The nucleotide sequences were deposited in the GenBank under accession numbers AF200855-AF200869, AF200871-AF200892, and AF200894-AF200921.