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Necrobiosis Lipoidica Diabeticorum

1958; American Medical Association; Volume: 78; Issue: 1 Linguagem: Inglês

10.1001/archderm.1958.01560070077009

2375-6772

MARVIN F. ENGEL,

Dermatological and Skeletal Disorders

Necrobiosis lipoidica diabeticorum is a chronic cutaneous disorder, occurring usually in females and found almost entirely on the anterior surface of the lower extremities. The lesions are characterized by single to multiple sharply demarcated, oval, firm, yellowish, shiny plaques with a violaceous border (Figs. 1 and 2). The purpose of this paper is not to review the literature on necrobiosis lipoidica diabeticorum, as this has been done in the past by Hildebrand, Montgomery, and Rynearson 1 and more recently by Hare, 2 but rather to attempt to resolve the still unanswered question of its relationship to diabetes mellitus. Studies were done to determine the formative mechanism of the vascular lesions, to show possible reasons for the common occurrence of the lesion at the anterior tibial region, and to determine the reason for its predominance in females. To accomplish these objectives, a study was made of