Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells
2011; Elsevier BV; Volume: 8; Issue: 2 Linguagem: Inglês
10.1016/j.stem.2010.11.029
ISSN1934-5909
AutoresShintaro Tanimura, Yuko Tadokoro, K Inomata, Nguyễn Thanh Bình, Wataru Nishie, Satoshi Yamazaki, Hiromitsu Nakauchi, Yoshio Tanaka, James R. McMillan, Daisuke Sawamura, Kim B. Yancey, Hiroshi Shimizu, Emi K. Nishimura,
Tópico(s)RNA regulation and disease
ResumoSummary In most stem cell systems, the organization of the stem cell niche and the anchoring matrix required for stem cell maintenance are largely unknown. We report here that collagen XVII (COL17A1/BP180/BPAG2), a hemidesmosomal transmembrane collagen, is highly expressed in hair follicle stem cells (HFSCs) and is required for the maintenance not only of HFSCs but also of melanocyte stem cells (MSCs), which do not express Col17a1 but directly adhere to HFSCs. Mice lacking Col17a1 show premature hair graying and hair loss. Analysis of Col17a1 -null mice revealed that COL17A1 is critical for the self-renewal of HFSCs through maintaining their quiescence and immaturity, potentially explaining the mechanism underlying hair loss in human COL17A1 deficiency. Moreover, forced expression of COL17A1 in basal keratinocytes, including HFSCs, in Col17a1 -null mice rescues MSCs from premature differentiation and restores TGF-β signaling, demonstrating that HFSCs function as a critical regulatory component of the MSC niche.
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