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Fish antibiotherapy: bioencapsulation of flumequine using adult brine shrimp (Artemia salina)

2007; Wiley; Volume: 38; Issue: 6 Linguagem: Inglês

10.1111/j.1365-2109.2007.01703.x

1365-2109

João Paulo Gomes, C.L. Vilela, Ricardo Bexiga, Gonçalo D Nunes, Nuno Pereira, Lina M. Cavaco,

Innovative Microfluidic and Catalytic Techniques Innovation

Aquaculture ResearchVolume 38, Issue 6 p. 613-617 Fish antibiotherapy: bioencapsulation of flumequine using adult brine shrimp (Artemia salina) João Gomes, João Gomes CIISA/Faculdade de Medicina Veterinária, Pólo Universitário do Alto da Ajuda, Av. da Universidade Técnica, Lisboa, PortugalSearch for more papers by this authorCristina Lobo Vilela, Cristina Lobo Vilela CIISA/Faculdade de Medicina Veterinária, Pólo Universitário do Alto da Ajuda, Av. da Universidade Técnica, Lisboa, PortugalSearch for more papers by this authorRicardo Bexiga, Ricardo Bexiga CIISA/Faculdade de Medicina Veterinária, Pólo Universitário do Alto da Ajuda, Av. da Universidade Técnica, Lisboa, Portugal Presently at the Faculty of Veterinary Medicine, University of Glasgow, Glasgow, UKSearch for more papers by this authorGonçalo D Nunes, Gonçalo D Nunes Oceanário de Lisboa, SA., Esplanada D. Carlos I- Doca dos Olivais; Lisboa, PortugalSearch for more papers by this authorNuno Pereira, Nuno Pereira Oceanário de Lisboa, SA., Esplanada D. Carlos I- Doca dos Olivais; Lisboa, PortugalSearch for more papers by this authorLina M Cavaco, Lina M Cavaco Presently at KVL University, Institute for Veterinary Pathology, Copenhagen, DenmarkSearch for more papers by this author João Gomes, João Gomes CIISA/Faculdade de Medicina Veterinária, Pólo Universitário do Alto da Ajuda, Av. da Universidade Técnica, Lisboa, PortugalSearch for more papers by this authorCristina Lobo Vilela, Cristina Lobo Vilela CIISA/Faculdade de Medicina Veterinária, Pólo Universitário do Alto da Ajuda, Av. da Universidade Técnica, Lisboa, PortugalSearch for more papers by this authorRicardo Bexiga, Ricardo Bexiga CIISA/Faculdade de Medicina Veterinária, Pólo Universitário do Alto da Ajuda, Av. da Universidade Técnica, Lisboa, Portugal Presently at the Faculty of Veterinary Medicine, University of Glasgow, Glasgow, UKSearch for more papers by this authorGonçalo D Nunes, Gonçalo D Nunes Oceanário de Lisboa, SA., Esplanada D. Carlos I- Doca dos Olivais; Lisboa, PortugalSearch for more papers by this authorNuno Pereira, Nuno Pereira Oceanário de Lisboa, SA., Esplanada D. Carlos I- Doca dos Olivais; Lisboa, PortugalSearch for more papers by this authorLina M Cavaco, Lina M Cavaco Presently at KVL University, Institute for Veterinary Pathology, Copenhagen, DenmarkSearch for more papers by this author First published: 05 April 2007 https://doi.org/10.1111/j.1365-2109.2007.01703.xCitations: 9 Correspondence: C Lobo Vilela, Microbiologia e Imunologia, Faculdade de Medicina Veterinaria, Avenida da Universidade Tecnica, 1300-477 Lisboa, Portugal. E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Optimization of antibiotic delivery strategies to aquatic environment and to the specific characteristics of the target species is essential for the improvement of bacterial infection control measures. This work aimed at standardizing the use of Artemia salina to deliver flumequine to fish as antimicrobial treatment. Adult Artemia were used to bioencapsulate flumequine. A flumequine concentration of 358 μg mL−1 was found adequate to perform bioencapsulation during 24 h without causing mortality. Antibiotic concentration in Artemia, quantified by means of a microbiological assay based on MIC determination, using Escherichia coli ATCC 25922 as control strain was 256.55 mg g−1 (±71.22). The therapeutic doses of 10 mg kg−1 BW, calculated on the basis of a consumption of about 4% BW/day, would then be delivered by the consumption of 7.8 Artemia g−1 of fish. Citing Literature Volume38, Issue6April 2007Pages 613-617 RelatedInformation