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The effect of insulin on macrophage metabolism and function

1996; Wiley; Volume: 14; Issue: 1 Linguagem: Inglês

10.1002/cbf.637

1099-0844

Luís Fernando Bicudo Pereira Costa Rosa, D A Safi, Yara Cury, Rui Curi,

Adipokines, Inflammation, and Metabolic Diseases

Abstract This study examined the effect of insulin on rat macrophage metabolism and function. The following parameters were studied: cell migration in response to thioglycollate and BCG stimuli, macrophage phagocytic capacity, H 2 O 2 production, glucose and glutamine metabolism as indicated by the measurement of enzyme activities, the utilization of metabolites and production and oxidation of substrates. The results indicate that insulin: (1) did not affect cell migration in response to thioglycollate and BCG; (2) enhanced the phagocytic capacity of macrophages and the production of H 2 O 2 by macrophages; (3) increased the metabolism of glucose and reduced that of glutaminase.