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Artigo Revisado por pares
BIBTEX RIS

Liver aldehyde oxidase: A form of xanthine oxidase

1960; Elsevier BV; Volume: 44; Linguagem: Inglês

10.1016/0006-3002(60)91566-3

ISSN

1878-2434

Autores

Robert P. Igo, Bruce Mackler,

Tópico(s)

Polyamine Metabolism and Applications

Resumo

Abstract Pig liver aldehyde oxidase is not specific for aldehydes, but in addition catalyzes the oxidation at reduced rates of hypoxanthine, xanthine and DPNH. The sites of binding of acetaldehyde and hypoxanthine by the enzyme appear to be different. Flavin is a component common to the pathways of oxidation of acetaldehyde and hypoxanthine. Quinacrine inhibits the enzymic catalysis by preventing the reduction of the flavin. The heme component present in preparations of the enzyme does not appear to be involved in the enzymic catalysis.

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