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Inhibition of Rat Heart Phosphodiesterase by some Rotenoids and Isoflavonoids

1983; Thieme Medical Publishers (Germany); Volume: 47; Issue: 04 Linguagem: Inglês

10.1055/s-2007-969996

1439-0221

E. Petkov, P Uzunov, Irena Kostova, T. Somleva, I. Ognyanov,

Synthesis and biological activity

Series of natural and semisynthetic rotenoids and isoflavonoids were studied for their inhibitory activity on cyclic AMP phosphodiesterase (PDE) in rat heart. Some of the compounds showed higher inhibitory activity than that of the most potent flavonoids. The chemical transformation of the starting natural compounds failed to increase their inhibitory potency. PDE inhibition was of a noncompetitive type.