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Clinical utility of the full blood count in identifying patients with pandemic influenza A (H1N1)

2013; Elsevier BV; Volume: 66; Issue: 6 Linguagem: Inglês

10.1016/j.jinf.2013.01.001

1532-2742

Zvi Shimoni, Joseph Glick, Paul Froom,

Viral Infections and Immunology Research

It might be important to identify patients with swine flu (H1N1) before the results of the polymerase chain reaction (PCR) are available in order to institute earlier treatment and prevention precautions. Previous studies have concluded that the complete blood count (CBC) parameters having clinical utility in the early diagnosis of H1N1 disease, include a low relative 1 Cunha B.A. Pherez F.M. Schoch P. Diagnostic importance of relative lymphopenia as a marker of swine influenza (H1N1) in adults. Clin Infect Dis. 2009; 49: 1454 Crossref PubMed Scopus (82) Google Scholar , 2 Hage J.E. Petelin A. Cunha B.A. Before influenza tests results are available can droplet precautions be instituted if influenza is suggested by leukopenia, relative lymphopenia or thrombopenia?. Am J Infect Control. 2011; 39: 619-670 Abstract Full Text Full Text PDF PubMed Scopus (11) Google Scholar , 3 Coskun O. Sener K. Yaman H. Ogur R. Relative lymphopenia and monocytosis may be considered as a surrogate marker of pandemic influenza A (H1N1). J Clin Virol. 2010; 47: 388-389 Abstract Full Text Full Text PDF PubMed Scopus (25) Google Scholar or absolute 4 Ong A.K. Chen M.I. Lin L. Tan A.S. New N.W. Barkhan T. et al. Improving the clinical diagnosis of influenza- a comparative analysis of new influenza A (N1N1) cases. PLoS One. 2009; 4: e8453 Crossref PubMed Scopus (61) Google Scholar , 5 Chiappini E. Galli L. Azzi A. Resti M. Bonsignori F. de Martino M. Lymphocytopenia as a marker for pandemic influenza A/H1N1 in children. J Med Virol. 2011; 83: 1-4 Crossref PubMed Scopus (9) Google Scholar lymphocyte count, total white blood cell counts, 1 Cunha B.A. Pherez F.M. Schoch P. Diagnostic importance of relative lymphopenia as a marker of swine influenza (H1N1) in adults. Clin Infect Dis. 2009; 49: 1454 Crossref PubMed Scopus (82) Google Scholar , 4 Ong A.K. Chen M.I. Lin L. Tan A.S. New N.W. Barkhan T. et al. Improving the clinical diagnosis of influenza- a comparative analysis of new influenza A (N1N1) cases. PLoS One. 2009; 4: e8453 Crossref PubMed Scopus (61) Google Scholar , 6 Chan P.A. Mermel L.A. Andrea S.B. Mcculloh R. Mills J.P. Echenique I. et al. Distinguishing characteristics between pandemic 2009–2010 influenza A (H1N1) and other viruses in patients hospitalized with respiratory illness. PLoS One. 2011; 6: e24734 Crossref PubMed Scopus (26) Google Scholar , 7 Jain S. Kamimoto L. Bramley A.M. Schmitz A.M. Benoit S.R. Louie J. et al. Hospitalized patients with 2009 H1N1 influenza in the United States, April–June 2009. N Engl J Med. 2009; 361: 1935-1944 Crossref PubMed Scopus (1485) Google Scholar a low lymphocyte/monocyte ratios, 8 Merkoulias G. Alexopoulos E. Belerzos T. Panagiotopoulou E. Jelastopulu E. Lymphocyte to monocyte ratio as a screening tool for influenza. PloS Curr. 2010; 2: RRN1154 PubMed Google Scholar a low neutrophil/lymphocyte ratios, 9 Indavarapu A. Akinapelli A. Neutrophils to lymphocyte ratio as a screening tool for swine influenza. Indian J Med Res. 2011; 134: 389-391 PubMed Google Scholar or platelet counts less than the lower limit of the reference interval. 1 Cunha B.A. Pherez F.M. Schoch P. Diagnostic importance of relative lymphopenia as a marker of swine influenza (H1N1) in adults. Clin Infect Dis. 2009; 49: 1454 Crossref PubMed Scopus (82) Google Scholar