Interleukin-6 is the Major Regulator of Acute Phase Protein Synthesis in Rat and Man
1989; Elsevier BV; Linguagem: Inglês
10.1016/b978-0-08-036149-9.50026-9
AutoresJosé V. Castell, Michael David, Jan‐Michael A. Klapproth, Peter C. Heinrich, Tilo Andus, Tammy L Geiger, M. José Gómez‐Lechón, Tomoya Hirano, T. Kishimoto,
Tópico(s)Liver Disease Diagnosis and Treatment
ResumoThe regulation of the major acute phase proteins by interleukin-6/hepatocyte-stimulating factor (IL-6/HSF), interleukin-1ß (IL-1ß) and tumor necrosis factor a (TNFa) was studied in rat hepatocyte primary cultures. IL-6 was found to be the most effective inducer of acute phase protein synthesis in vitro and also in vivo. IL-6 was rapidly removed from blood and detected on the surface of hepatocytes. Also in human hepatocyte primary cultures IL-6, when compared to IL-1ß and TNFa, exbihited the strongest capacity to stimulate acute phase protein synthesis.
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