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Dopamine by itself activates either D2, D3 or D1/D5 dopaminergic receptors in normal human T-cells and triggers the selective secretion of either IL-10, TNFα or both

2005; Elsevier BV; Volume: 169; Issue: 1-2 Linguagem: Inglês

10.1016/j.jneuroim.2005.07.013

1872-8421

Michal J. Besser, Yonatan Ganor, Mia Levite,

Neuropeptides and Animal Physiology

Abstract The neurotransmitter dopamine on its own increased significantly TNFα and IL-10 secretion by resting normal-human T-cells, and induced ∼5-fold elevation of the corresponding mRNA's, without affecting IFNγ and IL-4. Using seven highly selective dopamine-receptor (DR) agonists and antagonists we found that TNFα-upregulation, evident after 24 h, was mediated by D3R and D1/D5R while IL-10-upregulation, evident after 72 h, was mediated by D2R and D1/D5R. We confirmed the expression of D2R and D3R in these human T cells. Dopamine's unique ability to trigger a selective secretion of either TNFα only (via D3R) or IL-10 only (via D2R) or both (via D1/D5R), differs from the robust and non-selective cytokine-secretion induced by ‘classical' TCR-activation, and as such may have important beneficial or detrimental implications in various immunological and neurological diseases/injuries/cancers.