Antibacterial oleanane-type triterpenoids from pericarps of Akebia trifoliata
2014; Elsevier BV; Volume: 168; Linguagem: Inglês
10.1016/j.foodchem.2014.07.105
ISSN1873-7072
AutoresJing Wang, Hui Ren, Qiao-Lin Xu, Zhong‐Yu Zhou, Ping Wu, Xiaoyi Wei, Yong Cao, Xuexiang Chen, Jian‐Wen Tan,
Tópico(s)Plant Toxicity and Pharmacological Properties
ResumoThree new oleanane triterpenoids, 2α,3β,29-trihydroxyolean-12-en-28-oic acid (1), 2α,3β-dihydroxy-23-oxo-olean-12-en-28-oic acid (2) and 2α,3β,21β,22α-tetrahydroxyolean-12-en-28,29-dioic acid (3), and ten known ones, maslinic acid (4), arjunolic acid (5), oleanolic acid (6), 3-epi-oleanolic acid (7), stachlic acid A (8), serratagenic acid (9), gypsogenic acid (10), 2α,3β-dihydroxyol-ean-13(18)-en-28-oic acid (11), mesembryanthemoidigenic acid (12) and 12α-hydroxy-δ-lactone (13), were isolated from the pericarps of Akebia trifoliata, a new valued fruit crop in China. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 8, 10, 11 and 13 were isolated for the first time from the genus Akebia. All the compounds were tested for their antimicrobial activity against five bacterial strains. Compounds 4, 6 and 11 showed significant antibacterial activity toward all the assayed microorganisms with MIC values ranging from 0.9 to 15.6 μg/mL, which were close or even more potent than the reference compound Kanamycin (MIC values ranging from 1.9 to 3.9 μg/mL).
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