Cap Z(36/32), a barbed end actin-capping protein, is a component of the Z-line of skeletal muscle.
1987; Rockefeller University Press; Volume: 105; Issue: 1 Linguagem: Inglês
10.1083/jcb.105.1.371
ISSN1540-8140
AutoresJames F. Casella, Susan W. Craig, D J Maack, André EX Brown,
Tópico(s)Genetic Neurodegenerative Diseases
ResumoVarious biological activities have been attributed to actin-capping proteins based on their in vitro effects on actin filaments. However, there is little direct evidence for their in vivo activities. In this paper, we show that Cap Z(36/32), a barbed end, actin-capping protein isolated from muscle (Casella, J. F., D. J. Maack, and S. Lin, 1986, J. Biol. Chem., 261:10915-10921) is localized to the barbed ends of actin filaments by electron microscopy and to the Z-line of chicken skeletal muscle by indirect immunofluorescence and electron microscopy. Since actin filaments associate with the Z-line at their barbed ends, these findings suggest that Cap Z(36/32) may play a role in regulating length, orienting, or attaching actin filaments to Z-discs.
Referência(s)