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Antibodies to Interferon-α in Treated Cancer Patients: Incidence and Significance

1997; Mary Ann Liebert, Inc.; Volume: 17; Issue: 3 Linguagem: Inglês

10.1089/jir.1997.17.141

1557-7465

Rachel M. McKenna, Kjell E. Öberg,

Monoclonal and Polyclonal Antibodies Research

Antibodies to interferon-α (IFN-α) are found in some patients being treated with this cytokine. In studies in which two recombinant IFN-α preparations were directly compared in cancer patients, those given IFN-α2a were found to have neutralizing antibodies in their serum significantly more often than those given IFN-α2b (p <0.001). Patients who develop neutralizing antibodies are more likely to have a clinical relapse and to become resistant to further treatment with at least the IFN preparation initially used for their treatment. In 10 studies in cancer patients, such an outcome was found in 63% of those who developed antibodies but in only 13% of those who did not. These data are tabulated.