Endothelin-1 mRNA expression by peripheral blood monocytes in IgA nephropathy
1993; Elsevier BV; Volume: 342; Issue: 8880 Linguagem: Inglês
10.1016/0140-6736(93)92126-e
ISSN1474-547X
AutoresTsukasa Nakamura, Isao Ebihara, Isao Shirato, Mitsumine Fukui, Yasuhiko Tomino, Hikaru Koide,
Tópico(s)Ion Transport and Channel Regulation
ResumoWe investigated endothelin-1 mRNA zxpression in peripheral blood monocytes from 40 patients with IgA nephropathy, 40 with other glomerulonephritides and 10 with essential hypertension without renal siseases, and from 30 healthy age-matched controls. 95% of patients with IgA nephropathy had increased endothelin-1 mRNA expression in monocytes but little was detected from the other groups. Endothelin-1 mRNA was positively correlated with urinary protein excretion (95% CI 0·835–0·952) and histopathological findings (0·796–0·939). In 15 patients with IgA nephropathy endothelin-1 mRNA values and proteinuria decreased gradually after treatment. Endothelin-1 mRNA-expressing activated monocytes may be associated with the progression of IgA nephropathy. Lancet 1993; 342: 1147–48
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