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BIBTEX RIS

(−)-α-Bisabolol attenuates visceral nociception and inflammation in mice

2010; Elsevier BV; Volume: 82; Issue: 2 Linguagem: Inglês

10.1016/j.fitote.2010.09.012

1873-6971

Gerlânia de Oliveira Leite, Laura Hévila Inocêncio Leite, Renata de Souza Sampaio, Mariana K.A. Araruna, Irwin Rose Alencar de Menezes, José Galberto Martins da Costa, Adriana de Campos,

Phytochemistry and Biological Activities

The study examined the antiinflammatory and antinociceptive effects of the sesquiterpene (−)-α-bisabolol (BISA). The antiinflammatory effect was evaluated on acute models of dermatitis induced by Croton oil, arachidonic acid, phenol and capsaicin, respectively, in mouse ear. BISA inhibited the dermatitis induced by all noxious agents, except capsaicin. BISA was assessed in two established mouse models of visceral nociception. Mice were pretreated orally with BISA, and the pain-related behavioral responses to intraperitoneal cyclophosphamide or to intracolonic mustard oil were analyzed. BISA showed a dose-unrelated significant antinociception. Collectively, the results suggest that BISA may be an topical antiinflammatory and visceral antinociceptive agent.