Cystic fibrosis serum stimulates mucin secretion but not calcium efflux from rat submandibular acini
1983; Elsevier BV; Volume: 135; Issue: 2 Linguagem: Inglês
10.1016/0009-8981(83)90134-1
ISSN1873-3492
AutoresMargaret A. McPherson, J.A. Dodge, M C Goodchild,
Tópico(s)Salivary Gland Disorders and Functions
ResumoCystic fibrosis serum stimulated release of mucins from rat submandibular acini to a significantly greater degree than did control serum. This action was not due to non-specific cell lysis, as monitored by lactate dehydrogenase release and was not accompanied by increases in 45Ca2+-efflux. The actions of cystic fibrosis serum and control serum in stimulating amylase release from rat exocrine pancreatic acini could not be distinguished. Thus, a specific action of cystic fibrosis serum in increasing mucin secretion, but not calcium permeability, in rat exocrine acini has been demonstrated.
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