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HISTAMINE AFFECTS TESTICULAR STEROID PRODUCTION IN THE GOLDEN HAMSTER

1989; Oxford University Press; Volume: 125; Issue: 4 Linguagem: Inglês

10.1210/endo-125-4-2212

1945-7170

Artur Mayerhofer, Andrzej Bartke, ARMANDO G. AMADOR AND TIM BEGAN,

Aquatic life and conservation

Localization of mast cells in the testis and ability of histamine (HA) to stimulate testicular testosterone (T) production in vitro were examined in gonadally active adult golden hamsters, kept under a long daily photoperiod (LD) and in gonadally regressed adult golden hamsters exposed to an inhibitory short photoperiod (SD). In both groups mast cells were present in the capsule of the testes and occasionally in vicinity of intratesticular blood vessels. Histamine stimulated T production in a dose dependent manner in incubations of regressed testes of SD animals, but had no stimulatory effect in the active testes of LD animals. In the incubations ofSD testes, the effects of HA were abolished by the H-1 antagonist pyrilamine, but unaffected by the H-2 antagonist cimetidine. In both groups, HA enhanced the stimulatory effects of hCC. These results indicate that HA has steroidogenic activity in the testis and may bea factor involved in the regulationof Leydig cell function.