Structure, function and assembly of the nucleolus
1993; Elsevier BV; Volume: 3; Issue: 7 Linguagem: Inglês
10.1016/0962-8924(93)90123-i
ISSN1879-3088
AutoresUlrich Scheer, Marc Thiry, Guy Goessens,
Tópico(s)Genomics and Chromatin Dynamics
ResumoMost events of ribosome biogenesis--such as transcription of the ribosomal RNA (rRNA) genes, processing of their primary transcripts into mature rRNAs and assembly with ribosomal and nonribosomal proteins to form the preribosomes--are confined to a special nuclear compartment, the nucleolus. Immunogold labelling and in situ hybridization at the ultrastructural level are providing novel insights into structure-function relationships of the nucleolus, and in vitro systems are beginning to shed light on the molecular mechanisms involved in the reforming of nucleoli after mitosis.
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