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Viomycin. Part I. The structure of the guanidine-containing unit

1972; Linguagem: Inglês

10.1039/p19720000820

2050-8255

Barrie W. Bycroft, L. R. Croft, A. W. Johnson, T. E. Webb,

Chemical Synthesis and Analysis

Viomycidine, a bicyclic guanidino-amino-acid obtained from viomycin by acidic hydrolysis, is shown to be an artefact derived by cyclisation from a monocyclic guanidino-carbinol unit. Several reactions of viomycin find close analogies in the chemistry of tetrodotoxin, which also contains a guanidino-carbinol fragment. The structural relationship between viomycin and capreomycin has been established.