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Generation of chromosome size polymorphism during in vivo mitotic multiplication of Plasmodium berghei involves both loss and addition of subtelomeric repeat sequences

1990; Elsevier BV; Volume: 41; Issue: 1 Linguagem: Inglês

10.1016/0166-6851(90)90098-7

1872-9428

Marta Ponzi, Chris J. Janse, E. Dore, Raffaella Scotti, Tomasino Pace, T.J.F. Reterink, Frank M. van der Berg, Barend Mons,

HIV/AIDS drug development and treatment

Extensive chromosome size polymorphism arises in Plasmodium berghei during in vivo mitotic multiplication. Size differences between homologous chromosomes involve rearrangements occurring in the subtelomeric portions while internal chromosomal regions do not contribute significantly to chromosome size polymorphism. Differences in the copy number of a 2.3-kb subtelomeric repeated unit are shown to correlate with size variations, and in at least one case to account completely for the size difference between two variants of the same chromosome.