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Erythrocyte membrane lysophospholipase activity in muscular dystrophy

1983; Elsevier BV; Volume: 59; Issue: 3 Linguagem: Inglês

10.1016/0022-510x(83)90027-8

1878-5883

Janice L. Podolski, Harry J. Lubansky, Günseli Sarpel, Moris J. Danon, Eugene Lazowski, Akira Omachi,

Mitochondrial Function and Pathology

The membrane lysophospholipase activity of erythrocytes obtained from Duchenne muscular dystrophy patients was lower than that of erythrocytes from age-matched normal boys. On the other hand, the membrane enzyme activity of erythrocytes from myotonic dystrophy patients was not different from that of their age- and sex-matched controls. Dipyridamole (0.1 mM) and glycerol 3-phosphorylcholine (2 mM) had no significant effect on these enzyme activities. These results suggest that membrane lysophospholipid metabolism may be altered in Duchenne muscular dystrophy but not in myotonic dystrophy.