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Characterization of an Old Complex Circulating Recombinant Form, CRF27_cpx, Originating from the Democratic Republic of Congo (DRC) and Circulating in France

2008; Mary Ann Liebert, Inc.; Volume: 24; Issue: 2 Linguagem: Inglês

10.1089/aid.2007.0241

1931-8405

Nicole Vidal, Pierre Frange, Marie‐Laure Chaix, Claire Mulanga, François Bompeka Lepira, Samuel Edidi Bazepeo, Cécile Goujard, Laurence Meyer, Christine Rouzioux, Éric Delaporte, Martine Peeters,

Immune Cell Function and Interaction

Full-length genomes were characterized for two samples, 02CD-LBR024 from the Democratic Republic of Congo (DRC) and 04FR-CD-KZS from France, that formed a separate subcluster with a previously characterized env subtype E isolate from DRC with a recombinant structure different from CRF01-AE. Since the three viruses are clearly epidemiologically unlinked and share the same complex recombinant structure, they represent a circulating recombinant form, designated as CRF27-cpx. The recombination pattern involves six different HIV-1 subtypes (A, E, G, H, J, and K) and a small unclassified fragment. The genetic distances are relatively high, indicating that CRF27-cpx evolved over a long time. Their prevalence is low (0.75%) and remained stable over time in the DRC. The existence of the 04FR.CD.KZS virus, in a patient who recently seroconverted in France, confirmed that these strains now circulate outside the DRC. Continuous monitoring of HIV-1 strains thus remains important to allow early identification of the introduction of new variants.