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Prevention of injection pain due to propofol by dezocine: A comparison with lidocaine

2013; Medknow; Volume: 45; Issue: 6 Linguagem: Inglês

10.4103/0253-7613.121376

1998-3751

Ye Zhang, Yao Lu, GordonTin Chun Wong, Chunshan Dong, Yu Junma,

Nausea and vomiting management

The aim of this study was to investigate the efficacy of dezocine (DEZ) versus placebo control (CON) and 2% lidocaine (LID) in prevention of injection pain due to DEZ.A prospective randomized double-blind, placebo-CON study was conducted in 75 adults, American Society of Anesthesiologists physical status I or II, scheduled to undergo an elective surgery. A total of 25 patients were randomly assigned to one of the three groups, thus CON, group LID and group DEZ. The groups received either 2 ml of normal saline or 2 ml 2% LID or 2 mg/2 ml DEZ, respectively, as pre-treatment. Propofol was injected 1 min later. A blinded researcher assessed the patient's pain level using a four point verbal rating scale.Less patients experienced pain due to propofol injection in the LID (40%) and DEZ (28%) groups compared with the CON (84%) group (P < 0.05). Six patients (24%) in the CON group reported severe pain during propofol injection but none in the other two groups.Pre-treatment with DEZ decreases propofol injection pain as effectively as LID.