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Inotropic Activities of Imidazopyridines

1990; Wiley; Volume: 323; Issue: 8 Linguagem: Inglês

10.1002/ardp.19903230811

1521-4184

Paul Barraclough, J.W. Black, D. Cambridge, V.P. Gerskowitch, Robert A. D. Hull, Ramachandran Lyer, W. R. KING, Clare O. Kneen, M. S. NOBBS, Gita P. Shah, Steven Smith, S. J. VINE, M.V. Whiting,

Synthesis and Reactions of Organic Compounds

A series of 2-substituted 1H-imidazo[4,5-b]pyridines and the isomeric 1H-imidazo[4,5-c]pyridine derivatives has been prepared and evaluated as inotropic agents. The 1H-imidazo-[4,5-b] derivatives were found to be consistently more potent than their isomers in the [4,5-c] series in isolated guinea pig papillary muscle preparations. Structure-activity relationships and the species-dependence of inotropic potencies are discussed.