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Pharmacological Investigation of the Glucoside and Aglucone Isolated from Caccinia glauca

1962; Elsevier BV; Volume: 51; Issue: 11 Linguagem: Inglês

10.1002/jps.2600511106

1520-6017

H.R.K. Arora, Rashmi Arora,

Biological Activity of Diterpenoids and Biflavonoids

Abstract A glucoside and its aglucone isolated from Caccinia glauca were studied for their pharmacological activity. Both compounds exhibited a diuretic action which appeared to be due to an increase in glomerular filtration. The dose which induced diuresis did not have any other significant effects. Isolated tissue preparations were not affected except by very high concentrations. The compounds were effective by the oral as well as parenteral route and showed a large safety margin.