A structurally and biogenetically interesting moenomycin antibiotic
1995; Elsevier BV; Volume: 51; Issue: 7 Linguagem: Inglês
10.1016/0040-4020(94)01074-a
ISSN1464-5416
AutoresAstrid Donnerstag, Susanne Marzian, D. Müller, Peter Welzel, Dirk Böttger, Andreas M. Stark, Hans‐Wolfram Fehlhaber, Astrid Markus, Yveline van Heijenoort, Jean van Heijenoort,
Tópico(s)Genomics and Phylogenetic Studies
ResumoIsolation and structure elucidation of a new moenomycin antibiotic (A12, 1a) is reported that differs from moenomycin A by lack of the branching methyl group and by the configuration at C-4 of unit F. The smallest antibiotically active degradation product of 1a is the trisaccharide derivative 3a. This observation is in contrast to structure activity relations in the moenomycin A series where it was found that disaccharide 4b is fully active. An explanation is offered for this difference.
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