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Ketoprofen, acetaminophen plus oxycodone, and acetaminophen in the relief of postoperative pain

1993; Wiley; Volume: 54; Issue: 5 Linguagem: Inglês

10.1038/clpt.1993.187

1532-6535

Abraham Sunshine, Nancy Z. Olson, Itic Zighelboim, Ana de Castro,

Nausea and vomiting management

Clinical Pharmacology & TherapeuticsVolume 54, Issue 5 p. 546-555 Clinical Trials and Therapeutics Ketoprofen, acetaminophen plus oxycodone, and acetaminophen in the relief of postoperative pain Abraham Sunshine MD, Corresponding Author Abraham Sunshine MD New York University Medical Center and Analgesic Development Ltd., New York Hospital Maternidad Concepcion Palacios, CaracasAbraham Sunshine MD, Analgesic Development Ltd., 907 Fifth Ave., Suite 1 East, New York, NY 10021.Search for more papers by this authorNancy Z Olson MPS, Nancy Z Olson MPS New York University Medical Center and Analgesic Development Ltd., New York Hospital Maternidad Concepcion Palacios, CaracasSearch for more papers by this authorItic Zighelboim MD, Itic Zighelboim MD New York University Medical Center and Analgesic Development Ltd., New York Hospital Maternidad Concepcion Palacios, CaracasSearch for more papers by this authorAna De Castro RN, Ana De Castro RN New York University Medical Center and Analgesic Development Ltd., New York Hospital Maternidad Concepcion Palacios, CaracasSearch for more papers by this author Abraham Sunshine MD, Corresponding Author Abraham Sunshine MD New York University Medical Center and Analgesic Development Ltd., New York Hospital Maternidad Concepcion Palacios, CaracasAbraham Sunshine MD, Analgesic Development Ltd., 907 Fifth Ave., Suite 1 East, New York, NY 10021.Search for more papers by this authorNancy Z Olson MPS, Nancy Z Olson MPS New York University Medical Center and Analgesic Development Ltd., New York Hospital Maternidad Concepcion Palacios, CaracasSearch for more papers by this authorItic Zighelboim MD, Itic Zighelboim MD New York University Medical Center and Analgesic Development Ltd., New York Hospital Maternidad Concepcion Palacios, CaracasSearch for more papers by this authorAna De Castro RN, Ana De Castro RN New York University Medical Center and Analgesic Development Ltd., New York Hospital Maternidad Concepcion Palacios, CaracasSearch for more papers by this author First published: November 1993 https://doi.org/10.1038/clpt.1993.187Citations: 6 Presented in part at the Ninety-third Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics, Orlando, Fla., March 18–20, 1992. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Ketoprofen (Orudis) is a nonsteroidal anti-inflammatory drug that is currently approved in the United States for the management of mild to moderate pain. The objective of this trial was to determine the effectiveness of orally administered ketoprofen in the management of severe postoperative pain. This randomized, double-blind parallel study compared the efficacy and safety of single doses of 100 mg or 50 mg ketoprofen, the combination of 650 mg acetaminophen plus 10 mg oxycodone hydrochloride, 650 mg acetaminophen, or placebo in 240 patients with severe postoperative pain after cesarean section. Analgesia for the first dose was assessed over an 8-hour period. Multiple doses of 100 mg or 50 mg ketoprofen and the combination at half the dose (325 mg acetaminophen plus 5 mg oxycodone) were also assessed for up to 7 days. The 100 and 50 mg doses of ketoprofen and the combination were statistically superior to acetaminophen and placebo for many analgesic measures. A dose response was observed between the two doses of ketoprofen, with the 100 mg dose providing significantly greater analgesia over the lower dose. Ketoprofen, 100 mg, was at least as effective as the combination and its effects lasted longer, with the exception of hour 1 when the combination was superior. Remedication time for the group receiving 100 mg ketoprofen was significantly longer than for the other treatment groups. Significantly more patients who took repeated doses of the combination (84%) than those who took either dose of ketoprofen (70%) had adverse effects. Ketoprofen at both dose levels was shown to be effective, long-lasting, and well tolerated, and it should be considered as a viable option for the management of moderate to severe postoperative pain. Clinical Pharmacology and Therapeutics (1993) 54, 546–555; doi:10.1038/clpt.1993.187 Citing Literature Volume54, Issue5November 1993Pages 546-555 RelatedInformation