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The treatment of chilblains with nifedipine: the results of a pilot study, a double-blind placebo-controlled randomized study and a long-term open trial

2006; Oxford University Press; Volume: 120; Issue: 2 Linguagem: Inglês

10.1111/j.1365-2133.1989.tb07792.x

1365-2133

M.H.A. RUSTIN, Julia A. Newton, N.P. SMITH, Pauline M. Dowd,

Streptococcal Infections and Treatments

British Journal of DermatologyVolume 120, Issue 2 p. 267-275 The treatment of chilblains with nifedipine: the results of a pilot study, a double-blind placebo-controlled randomized study and a long-term open trial M.H.A. RUSTIN, M.H.A. RUSTIN Department of Dermatology, The Middlesex Hospital, Mortimer Street, London WiN 8AA.Search for more papers by this authorJULIA A. NEWTON, JULIA A. NEWTON Dowling Skin Unit, St. Thomas's Hospitals, London, U.K. Institute of Dermatology, St. Thomas's Hospitals, London, U.K.Search for more papers by this authorN.P. SMITH, N.P. SMITH Institute of Dermatology, St. Thomas's Hospitals, London, U.K.Search for more papers by this authorPAULINE M. DOWD, PAULINE M. DOWD Department of Dermatology, The Middlesex Hospital, Mortimer Street, London WiN 8AA.Search for more papers by this author M.H.A. RUSTIN, M.H.A. RUSTIN Department of Dermatology, The Middlesex Hospital, Mortimer Street, London WiN 8AA.Search for more papers by this authorJULIA A. NEWTON, JULIA A. NEWTON Dowling Skin Unit, St. Thomas's Hospitals, London, U.K. Institute of Dermatology, St. Thomas's Hospitals, London, U.K.Search for more papers by this authorN.P. SMITH, N.P. SMITH Institute of Dermatology, St. Thomas's Hospitals, London, U.K.Search for more papers by this authorPAULINE M. DOWD, PAULINE M. DOWD Department of Dermatology, The Middlesex Hospital, Mortimer Street, London WiN 8AA.Search for more papers by this author First published: February 1989 https://doi.org/10.1111/j.1365-2133.1989.tb07792.xCitations: 84AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat SUMMARY A pilot study, a double-blind placebo-controlled randomised study and a long term open trial have indicated that nifedipine is effective in the treatment of perniosis. At a dose of 20 mg to 60 mg daily, nifedipine significantly reduced the time to clearance of existing lesions and prevented the development of new chilblains. Nifedipine also reduced the pain, soreness and irritation of the lesions. A comparison of the pre-and post-treatment skin biopsies showed resolution of the dermal oedema and diminution of the perivascular infiltrate. An increase in cutaneous blood flow following administration of nifedipine suggests that the vasodilator action of this drug may be important in its action. Citing Literature Volume120, Issue2February 1989Pages 267-275 RelatedInformation