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Some Factors Affecting the Release of a Water-Soluble Drug from a Compressed Hydrophilic Matrix

1966; Elsevier BV; Volume: 55; Issue: 8 Linguagem: Inglês

10.1002/jps.2600550818

1520-6017

Herbert Lapidus, Nicholas G. Lordi,

Surfactants and Colloidal Systems

A number of factors controlling the rate of drug release from a hydrophilic matrix were investigated. The release of chlorpheniramine maleate from a hydrated methylcellulose matrix was found to be controlled largely by drug diffusivity rather than dissolution of polymer and water penetrability. The release pattern obtained appears to follow the theoretical relationships previously proposed for solid drugs dispersed in solid matrices. A number of factors controlling the rate of drug release from a hydrophilic matrix were investigated. The release of chlorpheniramine maleate from a hydrated methylcellulose matrix was found to be controlled largely by drug diffusivity rather than dissolution of polymer and water penetrability. The release pattern obtained appears to follow the theoretical relationships previously proposed for solid drugs dispersed in solid matrices.