Portal de Periódicos da CAPES

In Search of a Consensus Model of the Resting State of a Voltage-Sensing Domain

2011; Cell Press; Volume: 72; Issue: 5 Linguagem: Inglês

10.1016/j.neuron.2011.09.024

1097-4199

Ernesto Vargas, Francisco Bezanilla, Benoı̂t Roux,

Electrochemical Analysis and Applications

Voltage-sensing domains (VSDs) undergo conformational changes in response to the membrane potential and are the critical structural modules responsible for the activation of voltage-gated channels. Structural information about the key conformational states underlying voltage activation is currently incomplete. Through the use of experimentally determined residue-residue interactions as structural constraints, we determine and refine a model of the Kv channel VSD in the resting conformation. The resulting structural model is in broad agreement with results that originate from various labs using different techniques, indicating the emergence of a consensus for the structural basis of voltage sensing.