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BIBTEX RIS

Cross-linking chitosan-Fe(III), an oral phosphate binder: studies in vitro and in vivo

2001; Elsevier BV; Volume: 223; Issue: 1-2 Linguagem: Inglês

10.1016/s0378-5173(01)00727-x

1873-3476

Cristiani Bürger, Daniela Valcarenghi, Silvana Sandri, Clóvis Antônio Rodrigues,

Parathyroid Disorders and Treatments

The objective was to evaluate the in vitro and in vivo phosphate binding properties of cross-linked chitosan iron (III) (CH-Fe(III)-CL), a potential oral phosphate binder for treating hyperphosphatemia. At equilibrium, the in vitro phosphate binding of CH-Fe(III)-CL was 23.6 mg g(-1) for simulated gastrointestinal conditions. In hyperphosphatemic rats, CH-Fe(III)-CL was similar to iron sulfate in reducing serum phosphate by about 35%.