Concentrations of serotonin and its related substances in the cerebrospinal fluid of Parkinsonian patients and their relations to the severity of symptoms
1993; Elsevier BV; Volume: 150; Issue: 1 Linguagem: Inglês
10.1016/0304-3940(93)90111-w
ISSN1872-7972
AutoresHideo Tohgi, Takashi Abe, Satoshi Takahashi, Junko Takahashi, Humitoshi Hamato,
Tópico(s)Botulinum Toxin and Related Neurological Disorders
ResumoWe evaluated the concentrations of free and total serotonin (5-hydroxytryptamine, 5-HT) and its related substances in the cerebrospinal fluid from patients with Parkinson's disease (PD). The concentrations of total 5-HT, 5-hydroxytryptophan, kynurenine and 3-hydroxykynurenine decreased significantly in PD patients compared with controls. The concentration of total 5-HT had significant negative correlations with Hoehn and Yahr's stages, the severity of rigidity, akinesia and gait freezing; the correlation with gait freezing was most conspicuous.
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