Ultrastructure of human testicular tumors
1966; Wiley; Volume: 19; Issue: 12 Linguagem: Inglês
10.1002/1097-0142(196612)19
ISSN1097-0142
Autores Tópico(s)Sexual Differentiation and Disorders
ResumoCancerVolume 19, Issue 12 p. 1963-1983 ArticleFree Access Ultrastructure of human testicular tumors G. Barry Pierce Jr. MD, G. Barry Pierce Jr. MD Department of Pathology, The University of Michigan, Ann Arbor, Mich. 48104Search for more papers by this author G. Barry Pierce Jr. MD, G. Barry Pierce Jr. MD Department of Pathology, The University of Michigan, Ann Arbor, Mich. 48104Search for more papers by this author First published: December 1966 https://doi.org/10.1002/1097-0142(196612)19:12 3.0.CO;2-GCitations: 108AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Thirteen seminomas, 5 embryonal carcinomas and 3 teratocarcinomas were studied ultrastructurally to obtain information upon the histogenesis, pathogenesis and interrelationships of the tumors. The ultrastructure of seminoma closely mimicked abortive stages in spermatogenesis; no evidence of somatic differentiation was present. Tumor cells that closely resembled spermatocytes appeared to be the stem cells which originated the more differentiated elements of seminoma. Embryonal carcinoma, whether occurring alone or as a component of teratocarcinoma, was similar in its ultrastructure and bore no resemblance to that of seminoma. Moreover, these embryonal carcinomas were indisguishable from those of the mouse. Since embryonal carcinoma of the mouse has been shown to be the multipotential stem cell of murine teratocarcinomas, it seems reasonable to suppose that human embryonal carcinoma would also serve as the multipotential stem cells of human teratocarcinomas. A basis is established for the occurrence of multiple types of testicular tumor in one testis and for the histogenesis of the various germinal tumors of the testicle. References 1 Abell, M. R., and Holtz, F.: Testicular neoplasms in infants and children—I. Tumors of germ cell origin. Cancer 16: 965–981, 1963. 2 Adami, J. G.: Principles of Pathology—General Pathology, 2nd ed. London, Lea & Febiger, 1909. 3 Andres, J.: Contribution a la connaissance du chondriome—Etude de ses modification ultrastructurales pendant la spermatogenese. J. Ultrastruct. Res. Suppl. 3, 1962. 4 Askanazy, M.: Die teratome nach ihrem Bau, ihrem Verlauf, iher Genese und im Vergleich zum esperimentellen Teratoid. Verhandl. Deutsch. Path. 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